Classification accuracy of the rare symptoms and symptom combinations scales of the Structured Inventory of Malingered Symptomatology in three archival samples.

OBJECTIVE: The Structured Inventory of Malingered Symptomatology (SIMS; Widows & Smith, 2005) is a 75-item self-report measure intended to screen for potentially feigned symptoms of mental illness and/or cognitive impairment. We investigated the classification accuracy of 2 new detection scales (Rare Symptoms [RS] and Symptom Combinations [SC]) developed by Rogers, Robinson, and Gillard (2014) that appeared useful in identifying simulated mental disorder in their derivation sample of psychiatric inpatients. HYPOTHESIS: We hypothesized that the rates of classification accuracy Rogers et al. reported for these 2 scales would generalize to other samples in which the utility of the SIMS previously has been investigated. METHOD: We computed RS and SC scores from archival SIMS data collected as part of 3 research projects investigating malingering detection methods: (a) general population prison inmates and inmates in a prison psychiatric unit receiving treatment for mental disorder (N = 115), (b) college students (N = 196), and (3) community-dwelling adults (N = 48). RESULTS: Results supported the global classification accuracy of RS and SC but the suggested cut-score for both scales (>6) produced poor sensitivity. Lower potential cut-offs did, however, improve sensitivity to feigning somewhat while not excessively diminishing specificity. CONCLUSION: These results emphasize the importance of generalizability research when investigating the clinical utility of forensic mental health assessment methods, particularly specific decision rules used to classify individuals into discrete categories. (PsycInfo Database Record (c) 2020 APA, all rights reserved).

Temporal stability and dynamic convergence of the Personality Assessment Screener in a prison sample.

Although the Personality Assessment Screener (PAS; Morey, 1997) has garnered substantial research interest, the measure's temporal stability and sensitivity to change have remained largely uninvestigated. The present study employs a dynamic approach to investigating the convergent and discriminant validity of the PAS by examining relationships between temporal changes on the PAS and changes on external criterion measures, thereby exploring the extent to which changes on the PAS offer meaningful information regarding changes in psychological functioning. Data were obtained from a public dataset funded by the United States Department of Justice in which male inmates were administered various psychological measures at 5 time points spanning the course of a year. The PAS demonstrated appreciable stability across all testing intervals and the full study period, and temporal changes on the PAS correlated as expected with changes on both conceptually similar and distinct external criterion measures. These findings offer evidence to suggest that temporal variations across testing intervals are not fully explained by error, as conceptualized in classical test-retest analyses, but rather may indicate meaningful changes in functioning. (PsycINFO Database Record (c) 2020 APA, all rights reserved).

Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet.

Morbidly obese patients who accomplish substantial weight loss often display a long-term decline in their resting metabolism, causing even relatively restrained caloric intake to trigger a relapse to the obese state. Paradoxically, we observed that morbidly obese mice receiving chemotherapy for cancer experienced spontaneous weight reduction despite unabated ingestion of their high fat diet (HFD). This response to chemotherapy could also be achieved in morbidly obese mice without cancer. Optimally dosed methotrexate (MTX) or cyclophosphamide (CY) enabled the mice to completely and safely normalize their body weight despite continued consumption of obesogenic quantities of HFD. Weight reduction was not attributable to decreased HFD intake, enhanced energy expenditure or malabsorption. MTX or CY dosing significantly depleted both adipose tissue and preadipocyte progenitors. Remarkably, however, despite continued high fat feeding, a compensatory increase in hepatocyte lipid storage was not observed, but rather the opposite. Gene microarray liver analyses demonstrated that HFD mice receiving MTX or CY experienced significantly inhibited lipogenesis and lipid storage, whereas Enho (energy homeostasis) gene expression was significantly upregulated. Further metabolic studies employing a human hepatocellular line revealed that MTX treatment preserved robust oxidative phosphorylation, but also promoted mitochondrial uncoupling with a surge in proton leak. This is the first report that certain optimally dosed chemotherapeutic agents can induce weight loss in morbidly obese mice without reduced dietary intake, apparently by depleting stores of adipocytes and their progenitors, curtailment of lipogenesis, and inconspicuous disposal of incoming dietary lipid via a steady state partial uncoupling of mitochondrial oxidative phosphorylation.